[Taxacom] Primate miRNA

John Grehan jgrehan at sciencebuff.org
Thu Nov 6 14:36:06 CST 2008


That wording would not be so bad as it would at least be a prediction.

John


> -----Original Message-----
> From: taxacom-bounces at mailman.nhm.ku.edu [mailto:taxacom-
> bounces at mailman.nhm.ku.edu] On Behalf Of Karl Magnacca
> Sent: Thursday, November 06, 2008 2:25 PM
> To: TAXACOM at mailman.nhm.ku.edu
> Subject: Re: [Taxacom] Primate miRNA
> 
> On Thu, November 6, 2008 6:38 pm, John Grehan wrote:
> > Zhang et al 2008. Mol Biol Evol 25: 1493-1502. Molecular evolution
of a
> > primate-specific microRNA family.
> >
> > p. 1495. "It was shown that mouse, rate, and dog do not have
homologs of
> > the miRNAs in this family; therefore, the emergence and rapid
expansion
> > of this miRNA family ARE RESTRICTED TO PRIMATES" (emphasis mine).
The
> > last bit seems to be stupid because there is nothing to preclude
this
> > family being in any other non-primate group. Am I wrong on this?
> 
> Rodents + lagomorphs are sister to primates (with some small groups
> thrown in) and carnivores are part of the group sister to that, so for
> the miRNAs to be ancestral would require two losses, or a loss and a
> gain.  The sentence probably should have been phrased as "likely
> restricted to primates", but it's a reasonable conclusion.
> 
> Karl
> =====================
> Karl Magnacca
> Postdoctoral Researcher
> Department of Zoology
> Trinity College, Dublin 2
> Ireland
> 
> 
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